Rat somatic genome editing enables ER+ breast cancer modeling
Wen Bu, Tobie D. Lee, Meenakshi Anurag, Yongchao Dou, Yunfeng Ding, Zhiao Shi, Alexandria Z. Bu, Lillian He, Chandandeep S. Nagi, Carolina Gutiérrez, Jing Wang, Susan Galloway Hilsenbeck, Chonghui Cheng, Bing Zhang, Shixia Huang, , Yi Li
This study enables efficient somatic genome editing in rats to model ER+ breast cancer, showing that rat tumors recapitulate key features of human ER+ breast cancer not observed in mice.
Proceedings of the National Academy of Sciences · Jun 22, 2026Peer-reviewedCancer Biology