Susan Galloway Hilsenbeck

Rat somatic genome editing enables ER+ breast cancer modeling

This study enables efficient somatic genome editing in rats to model ER+ breast cancer, showing that rat tumors recapitulate key features of human ER+ breast cancer not observed in mice.

Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids

This study uses human nasal epithelial organoids to investigate how different bacteria colonize nasal tissue and induce cytokine responses, finding differential effects on chemokines and inflammasome signaling.

A Comprehensive Atlas of AAV Tropism in the Mouse

This paper maps the tissue tropism of ten AAV serotypes in mice after systemic delivery, identifying liver preference and unexpected transduction in adrenals, testes, and ovaries.

Patient-Derived Xenograft-Guided Prediction of Chemotherapy Response in Triple-Negative Breast Cancer

This paper develops chemotherapy-specific predictors for triple-negative breast cancer using patient-derived xenografts and multi-omic data, achieving high AUROC scores for response prediction.

The Signaling Pathways Project: an integrated ‘omics knowledgebase for mammalian cellular signaling pathways

Signaling Pathways Project maps over 10,000 transcriptomic and ChIP-Seq experiments to signaling nodes and ranks node targets by meta-analysis (consensomes), validated against literature and bench assays.