Kimberley Burrows

A framework for conducting time-varying genome-wide association studies: An application to body mass index across childhood in six multiethnic cohorts

The paper introduces a framework for time-varying GWAS to identify age-varying genetic effects on BMI across childhood, finding 28 genome-wide significant variants, including a novel one in DAOA.

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

This study uses Mendelian randomization to assess the causal effect of sexual behavior on oropharyngeal cancer risk, finding attenuated associations after adjusting for confounders.

Germline TYK2 mutation and cancer risk

The paper uses a genetic variant to assess cancer risk associated with TYK2 inhibition, finding increased risks for lung cancer and non-Hodgkin lymphoma.

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

This study identifies 100 loci associated with mitochondrial DNA copy number and finds causal links between mitochondrial function and mortality.

Mendelian randomisation study exploring the associations of serum folate with pan and site-specific cancers

This paper uses Mendelian randomisation to investigate the causal relationship between genetically predicted serum folate levels and cancer risk, finding little evidence of a causal association.

Smoking, DNA methylation and lung function: a Mendelian randomization analysis to investigate causal relationships

This study uses Mendelian randomization to investigate causal relationships between smoking-associated DNA methylation and lung function, identifying 18 CpGs with potential causal effects on FEV1.

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

This paper conducts a genome-wide association study of mitochondrial DNA copy number in two cohorts, identifying potential loci and highlighting the need for larger studies.