Jason A. MacGurn

The paper shows that excess methionine triggers growth arrest via Gcn2 activation, which depends on methionine transporter endocytosis.

This study shows that sphingolipid metabolism influences mitochondrial morphology changes in aging yeast cells and during oxidative stress.

This study shows PLD3 regulates lysosomal morphology, biogenesis, and function in neurons by affecting protein abundance, subcellular location, and clearance of aggregated proteins.

This study shows that ER-phagy drives age-related ER remodeling and lifespan, revealing it as a protective mechanism in aging.

This study investigates how myriocin, a sphingolipid biosynthesis inhibitor, enhances longevity by modulating ubiquitination and proteostasis networks in yeast.