Célia Caillet‐Saguy

This paper identifies small molecules that inhibit the SARS-CoV-2 E protein interaction with ZO-1 PDZ2 using X-ray crystallography, HTRF screening, and docking simulations, with one compound showing antiviral activity.

This study shows that the SARS-CoV-2 E protein's PDZ-binding motif enhances virulence by disrupting epithelial barriers and inflammation, but not neuroinvasion.