Nicolas Wolff

Structural insights into the inactive state of the adhesion GPCR ADGRV1

This study presents the cryo-EM structure of inactive ADGRV1 and shows it has weak constitutive activation and an alternative activation mechanism distinct from other aGPCRs.

HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2

This paper identifies small molecules that inhibit the SARS-CoV-2 E protein interaction with ZO-1 PDZ2 using X-ray crystallography, HTRF screening, and docking simulations, with one compound showing antiviral activity.

The SARS-CoV-2 envelope PDZ Binding Motif acts as a virulence factor disrupting host's epithelial cell-cell junctions

This study shows that the SARS-CoV-2 E protein's PDZ-binding motif enhances virulence by disrupting epithelial barriers and inflammation, but not neuroinvasion.

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.