Author

Tin-Chi Lin

Biogen (United States)ORCID 0000-0001-5098-6902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:proteomics· 3 Research Focus:GWAS / association mapping· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

Benjamin B. SuniD· 2 shared Biogen Biobank Team· 2 shared Kyle L. FerberiD· 2 shared Aimée M. DeatoniD· 1 shared Alnylam Human Genetics· 1 shared Anil RajiD· 1 shared Anubha MahajaniD· 1 shared Anurag SethiiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersGenetic & Genomic Medicine

Benjamin B. SunORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

xOmicsShiny: an R Shiny application for cross-omics data analysis and pathway mapping

Benbo Gao, Yu Huining Sun, Xinmin Zhang, Tin-Chi Lin, Wei Li, Romi Admanit, Baohong Zhang

xOmicsShiny is an R Shiny application that enables cross-omics data analysis and pathway mapping with visualization and analytical tools.

Bioinformatics Advances · Dec 26, 2024Peer-reviewedBioinformatics

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank

Robert Francis Hillary, Danni A. Gadd, Zhana Kuncheva, Tasos Mangelis, Tin-Chi Lin, Kyle L. Ferber, Helen McLaughlin, Heiko Runz, Biogen Biobank Team, Eric Marshall, Riccardo Emilio Marioni, Christopher N. Foley, Benjamin B. Sun

This study identifies gene-environment interactions affecting plasma proteins in UK Biobank, discovering 683 vQTLs and over 1,400 GEIs across 571 proteins.

Nature Communications · Aug 26, 2024Peer-reviewedGenetic & Genomic Medicine

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants

Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi‐Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, , Christopher D. Whelan

The paper maps genetic associations with plasma proteins in 54,306 UK Biobank participants, identifying 10,248 new protein quantitative trait loci (pQTLs) and expanding the genetic architecture of the plasma proteome.

Nature · Oct 4, 2023Peer-reviewedGenetics

A novel method for quantitation of AAV genome integrity and residual DNAs using duplex digital PCR

Lauren Tereshko, Xiaohui Zhao, Jake Gagnon, Tin-Chi Lin, Trevor Ewald, Marina S. Feschenko, Cullen Mason

This paper introduces a novel model to improve the accuracy and quantifiable range of duplex ddPCR assays for assessing AAV genome integrity.

bioRxiv · Jul 19, 2023 · PreprintMolecular Biology