Author

Biogen Biobank Team

Biogen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 5 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 7 Organism:human· 7 Approach:statistical model· 7 Assay:whole-exome sequencing· 3 Assay:proteomics· 2 Assay:GWAS summary statistics· 1 Assay:imaging· 1

Frequent Co-Authors

Heiko RunziD· 6 shared Benjamin B. SuniD· 5 shared Chia‐Yen CheniD· 5 shared Christopher D. WhelaniD· 3 shared Christopher N. FoleyiD· 3 shared Ellen A. TsaiiD· 3 shared Eric Marshall· 3 shared Aarno V. PalotieiD· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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6 shared papersGenetic & Genomic Medicine

Heiko RunzORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank

Robert Francis Hillary, Danni A. Gadd, Zhana Kuncheva, Tasos Mangelis, Tin-Chi Lin, Kyle L. Ferber, Helen McLaughlin, Heiko Runz, Biogen Biobank Team, Eric Marshall, Riccardo Emilio Marioni, Christopher N. Foley, Benjamin B. Sun

This study identifies gene-environment interactions affecting plasma proteins in UK Biobank, discovering 683 vQTLs and over 1,400 GEIs across 571 proteins.

Nature Communications · Aug 26, 2024Peer-reviewedGenetic & Genomic Medicine

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants

Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi‐Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, , Christopher D. Whelan

The paper maps genetic associations with plasma proteins in 54,306 UK Biobank participants, identifying 10,248 new protein quantitative trait loci (pQTLs) and expanding the genetic architecture of the plasma proteome.

Nature · Oct 4, 2023Peer-reviewedGenetics

Rare genetic variants impact muscle strength

Yunfeng Huang, Dóra Bodnár, Chia‐Yen Chen, Gabriela Sánchez-Andrade, Mark Sanderson, Biogen Biobank Team, Christopher D. Whelan, Paola G. Bronson, David Sexton, Sally John, Eric Marshall, Mehool Patel, Saranya Duraisamy, Timothy Swan, Denis A. Baird, , Heiko Runz

This study identifies six genes associated with hand grip strength using rare protein-coding variants in 340,319 individuals and shows additive effects with common variants.

Nature Communications · Jun 10, 2023Peer-reviewedGenetic & Genomic Medicine

The impact of rare protein coding genetic variation on adult cognitive function

Chia‐Yen Chen, Ruoyu Tian, Tian Ge, Max Lam, Gabriela Sánchez-Andrade, Tarjinder Singh, Lea Urpa, Jimmy Z. Liu, Mark Sanderson, Christine Rowley, Holly Ironfield, Terry Fang, Biogen Biobank Team, The SUPER-Finland study, Aija Kyttälä, , Heiko Runz

This study identifies eight genes associated with adult cognitive function through rare coding variants and shows how KDM5B dosage affects cognitive traits in mice and humans.

Nature Genetics · May 25, 2023Peer-reviewedGenetic & Genomic Medicine

Genetic associations of protein-coding variants in human disease

Benjamin B. Sun, Mitja Kurki, Christopher N. Foley, Asma Mechakra, Chia‐Yen Chen, Eric Marshall, Jemma B. Wilk, Biogen Biobank Team, Chia-Yen Ghen, Heiko Runz, Mohamed Chahine, Philippe Chevalier, Georges Christé, FinnGen, Aarno V. Palotie, Mark J. Daly

This study combines sequencing and genotyping data from two biobanks to identify 975 protein-coding variant associations across 744 disease endpoints, enhancing understanding of genetic disease mechanisms and drug targets.

Nature · Feb 23, 2022Peer-reviewedGenetic & Genomic Medicine

Genetic map of regional sulcal morphology in the human brain

Benjamin B. Sun, Stephanie J. Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N. Painter, Christopher N. Foley, Biogen Biobank team, Megan E. Jensen, Donald G. McLaren, Sai Spandana Chintapalli, Alyssa H. Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, , Christopher D. Whelan

This study identifies 388 genetic associations with regional brain sulcal morphology using UK Biobank data, highlighting gene expression and eQTL patterns and providing a 3D visualization resource.

bioRxiv · Oct 13, 2021 · PreprintGenomics

Whole exome sequencing in the UK Biobank reveals risk gene SLC2A1 and biological insights for major depressive disorder

Ruoyu Tian, Tian Ge, Jimmy Z. Liu, Max Lam, Biogen Biobank team, Daniel F. Levey, Joel E. Gelernter, Murray B. Stein, Ellen A. Tsai, Hailiang Huang, Todd Lencz, Heiko Runz, Chia‐Yen Chen

The paper analyzes whole exome sequencing data from the UK Biobank to identify rare coding variants associated with major depressive disorder and reveals genetic overlaps with other psychiatric disorders.

medRxiv · May 4, 2021 · PreprintGenetic & Genomic Medicine