Olaf Jahn

Fatty acid binding protein-8 (FABP8/PMP2) reveals molecular heterogeneity of myelin sheaths in the human CNS

This paper identifies FABP8/PMP2 as a defining feature of human and old-world monkey CNS myelin, revealing molecular heterogeneity in myelin sheaths and its role in cholesterol enrichment.

Aggregation-Dependent Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies

This study characterizes the binding and modification requirements of 20 anti-Aβ antibodies across different Aβ forms, revealing aggregation-dependent sequence and modification selectivity.

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

This study shows that AP2 complex is essential for myelin sheath biogenesis and homeostasis, with loss of AP2 causing hypomyelination and hypermyelination in different developmental stages.

Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

Phosphorylation Determines Whether Neuroligin-3 is at Excitatory or Inhibitory Synapses in Different Regions of the Brain

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

The paper compares myelin proteome and oligodendrocyte transcriptome profiles between humans and mice, finding both conservation and divergence in specific proteins and genes.

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

This study shows that CMTM5 deficiency in oligodendrocytes leads to progressive axonopathy, suggesting its role in maintaining axonal integrity rather than myelin formation.

Myelin lipids as nervous system energy reserves

The paper shows that myelin acts as an energy reserve in the brain under glucose deprivation, supporting oligodendrocytes and axons through fatty acid oxidation.

White matter integrity requires continuous myelin synthesis at the inner tongue

This study shows that continuous myelin synthesis is necessary for maintaining white matter integrity, as preventing new myelin formation in adult mice leads to myelin degradation and neurological disease.

The Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.

This study shows that Ube3b regulates dendritic branching and synaptic function by ubiquitinating Ppp3cc, contributing to intellectual disability-like phenotypes in a KOS mouse model.

Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2

The paper identifies Kir4.1 and Connexin43 as Nedd4-2 substrates, showing their regulation impacts astrocytic function and neuronal network activity.

Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix

This study identifies Complexin as a conserved vesicular protein that interacts with Bruchpilot's C-terminus to tether synaptic vesicles to the active zone cytomatrix in Drosophila and mouse synapses.