UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis
Ekaterina V. Borisova, Katherine J. Cuthill, Rike Dannenberg, Janina Koch, Julius Nowaczyk, Theres Schaub, Manuela Schwark, Nicolai Kastelić, Ivanna Kupryianchyk-Schultz, Marieluise Kirchner, Tancredi Massimo Pentimalli, Thornton J. Fokkens, Frank Stein, Carola Dietrich, Claudia Quedenau, , Mateusz C. Ambrozkiewicz
The paper shows UBE3C regulates cortical neurogenesis and glial fate through m6A methylation, with mutations disrupting this process and offering therapeutic targets.
bioRxiv · Apr 9, 2025 · PreprintNeuroscience