Nicholas J. Silva

The paper shows ECM proteolysis, specifically via MMP14 and brevican, maintains dynamic synapse plasticity during brain development in zebrafish and human iPSC-derived cultures.

The paper shows type 1 lymphocytes produce interferon-γ in the thalamus after brain injury, reducing seizure susceptibility by limiting neural hyperexcitability.

This study shows that microglial cathepsin B is essential for efficient neuronal efferocytosis during brain development, preventing apoptotic cell accumulation and ensuring proper neural circuit formation.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

The paper compares gene regulatory networks in zebrafish retinal regeneration and development after different neuronal subtype losses, finding both similarities and differences.

The paper identifies distinct microglial subsets in zebrafish brains that perform different phagocytic functions using single-cell RNA sequencing and spatial analysis.

This study shows that inflammation and Mmp-9 regulate photoreceptor regeneration in adult zebrafish, with Mmp-9 required for cone maturation and survival.