Mette Habekost

Transient matrix remodeling during direct cell-fate reprogramming enables self-assembly of dense neuronal niches

This paper describes a method to generate dense neuronal microcultures by combining fibroblast reprogramming with matrix remodeling in collagen microgels.

Cografting strategies uncover cell type dependent regulation of dopamine neuron specification and functional maturation in a pre clinical model of Parkinson`s Disease

This study investigates how co-grafting strategies influence dopamine neuron specification and maturation in a Parkinson's disease model, identifying key transcription factors involved in the process.

Injectable 3D microcultures enable intracerebral transplantation of mature neurons directly reprogrammed from patient fibroblasts

This study develops a 3D microculture method to generate mature dopamine neurons from patient fibroblasts, which can be transplanted into a Parkinson's disease rat model to form functional neuron grafts.

APP and its intracellular domain modulate Alzheimers disease risk gene networks in transgenic APPsw and PSEN1M146I porcine models

This study uses transgenic porcine models to show that APP and its AICD domain modulate AD-related gene networks through interactions with signaling proteins.