Robert A. Policastro

The Drosophila Estrogen-Related Receptor promotes triglyceride storage within the larval fat body

This study investigates the role of dERR in regulating lipid metabolism in Drosophila larval fat body, showing it promotes TAG accumulation and interacts with dHNF4.

Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster

This study shows that L2hgdh in Drosophila renal tubules prevents L-2HG accumulation, supports mitochondrial metabolism, and enables hypoxia tolerance.

Glycolytic Disruption Triggers Interorgan Signaling to Nonautonomously Restrict Drosophila Larval Growth

The paper shows that disrupting glycolysis in Drosophila larvae leads to systemic cytokine signaling changes, nonautonomously restricting growth.

Flexible analysis of TSS mapping data and detection of TSS shifts with TSRexploreR

The paper introduces TSRexploreR, an R package for analyzing TSS mapping data, including TSS/TSR detection, normalization, and shift detection.

ChEC-seq produces robust and specific maps of transcriptional regulators

The paper reanalyzes ChEC-seq data to show that short-duration experiments produce specific transcription factor binding maps in budding yeast.

Simple and efficient measurement of transcription initiation and transcript levels with STRIPE-seq

STRIPE-seq provides a simple, rapid, and cost-effective method for TSS profiling and transcript level measurement in yeast and human cells.

A Cyclin A - Myb-MuvB - Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles.

The paper identifies a Cyclin A - Myb-MuvB - Aurora B network that regulates the switch from mitotic to endoreplication cycles in Drosophila, showing its role in both developmental and induced endoreplication.