Khadijah Mazhar

The paper identifies microglia-like cells in human dorsal root ganglia and shows their changes in diabetic neuropathy.

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper identifies a right-biased neuronal population in vagus nerves that expresses genes related to digestive signaling and may contribute to asymmetric reward processing.

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.

This study uses bulk and spatial RNA sequencing to analyze human peripheral nerves in diabetic patients, revealing pathway differences, immune cell shifts, and mRNA localization changes linked to diabetic peripheral neuropathy.

This study uses snRNA-seq to identify molecular features of human airway microfold cells and discovers a novel epithelial cell type with an interferon-stimulated gene signature.

The paper characterizes human C2 dorsal root ganglion (DRG) using single-nucleus and spatial transcriptomics, identifying gene expression patterns linked to chronic neck pain.

The paper examines sex differences in the epigenomic landscape of human dorsal root ganglia, identifying sex-specific chromatin accessibility and transcription factor binding patterns associated with nociceptive gene regulation.

The paper identifies Nageotte nodules in diabetic painful neuropathy DRGs, showing they contain dead neurons and are linked to pain and sensory loss.

This study identifies enteric glia as a key cellular target for early life stress and biological sex in promoting gastrointestinal dysfunction similar to human DGBI.