Asta Arendt-Tranholm

Prolactin Receptor Long Isoform ΔS1 Expression is Reduced in the Dorsal Root Ganglia of Humans with Chronic Pain

The paper examines PRLR isoform expression in human dorsal root ganglia, finding higher PRLR-L (ΔS1) expression in females and reduced expression in females with chronic pain.

Conserved Axonal Transcriptome Dynamics Underlie PGE2-Induced Sensitisation and Identify Tnfrsf12a/Fn14 as a Regulator of Neuronal Excitability in DRG Neurons

The paper identifies a conserved axonal transcriptome involved in PGE2-induced sensitisation and shows Tnfrsf12a regulates neuronal excitability in DRG neurons.

History of opioid use disorder correlates with altered neuroimmune signatures in the human dorsal root ganglia

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

T-cell distribution in the dorsal root ganglion across species, sex, and age

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

A Reference Atlas of the Human Dorsal Root Ganglion

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

Nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barre syndrome

This study identifies transcriptomic signatures in GBS patients that reveal leukocyte interactions with peripheral nerves and pain pathways, suggesting therapeutic targets for neuropathic pain.

Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types

This paper identifies cell-type-specific genetic variants associated with chronic pain using GWAS and scRNA-seq data from brain and dorsal root ganglia tissues.

Single-cell characterization of the human C2 dorsal root ganglion recovered from C1-2 arthrodesis surgery: implications for neck pain

The paper characterizes human C2 dorsal root ganglion (DRG) using single-nucleus and spatial transcriptomics, identifying gene expression patterns linked to chronic neck pain.

RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing

The paper uses long-read sequencing to characterize RNA isoform expression in human dorsal root ganglia, identifying novel splice-junctions and isoforms of pain-related genes.