The paper develops a multi-omics cohort of prefrontal cortex data from cognitively normal older adults to identify molecular signatures of cognitive resilience to Alzheimer's disease.

bioRxiv · Sep 6, 2026 · PreprintGenomics

Human brain aging heterogeneity observed from multi-region omics data reveals a subtype closely related to Alzheimer's disease

Shouneng Peng, Erming Wang, Minghui Wang, Xusheng Wang, Kaiwen Yu, Yingxue Fu, Suresh Poudel, Lap Ho, Sushma Narayan, Derek M. Huffman, Chris Gaiteri, David A. Bennet, Michelle E. Ehrlich, Vahram H. Haroutunian, Junmin Peng, , Zhidong Tu

The paper identifies an AD-like subtype in brain aging across multiple regions, showing overlap with AD gene signatures and regional differences in gene expression.

bioRxiv · Mar 1, 2024 · PreprintNeuroscience

Single-cell Transcriptomic Atlas of the Human Substantia Nigra in Parkinson's Disease

Qian Wang, Minghui Wang, Insup Choi, Lap Ho, Kurt W. Farrell, Kristin G. Beaumont, Robert Sebra, John F. Crary, David A. Davis, Xiaoyan Sun, Bin Zhang, Zhenyu Yue

This study generates a large single-cell RNA sequencing dataset of the human substantia nigra in Parkinson's disease, identifies DA neuron subtypes, and reveals molecular changes associated with PD.

bioRxiv · Mar 25, 2022 · PreprintNeuroscience

Molecular Networks and Key Regulators of the Dysregulated Neuronal System in Alzheimer’s Disease

Minghui Wang, Aiqun Li, Michiko Sekiya, Noam D. Beckmann, Xiuming Quan, Nadine Schrode, Michael B. Fernando, Alex Yu, Li Zhu, Jiqing Cao, Liwei Lyu, Emrin Horgusluoglu, Qian Wang, Lei Ming Guo, Yuanshuo Wang, , Bin Zhang

This study identifies molecular networks and key regulators in Alzheimer’s Disease using integrative genomics and experimental validation.

bioRxiv · Oct 1, 2019 · PreprintNeuroscience