Author

Nicola Fattorelli

Vlaams Instituut voor BiotechnologieORCID 0000-0001-5564-8179Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Bart De StrooperiD· 3 shared Mark W. E. J. FiersiD· 3 shared Renzo MancusoiD· 3 shared Annerieke S. R. SierksmaiD· 2 shared Catherine M. VerfaillieiD· 2 shared Johanna Van Den DaeleiD· 2 shared Leen WolfsiD· 2 shared Lutgarde SerneelsiD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Bart De StrooperORCID

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3 papers

Recent·Most cited

NeuroscienceNature NeurosciencePeer-reviewedMar 27, 2024

A multi-pronged human microglia response to Alzheimer's disease Aβ pathology

Renzo Mancuso, Nicola Fattorelli, Anna Martínez‐Muriana…·Bart De Strooper

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

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humanscRNA-seq

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NeuroscienceEMBO Molecular MedicinePeer-reviewedJan 17, 2020

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

Annerieke S. R. Sierksma, Ashley Lu, Renzo Mancuso…·Mark W. E. J. Fiers

The paper identifies AD risk genes that influence microglia response to amyloid-β but not TAU pathology in mouse models.

291 citationstop 1%

mousebulk RNA-seq

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NeuroscienceNature NeurosciencePeer-reviewedOct 28, 2019

Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer's Disease

Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli…·Bart De Strooper

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.

295 citationstop 1%

mousehuman

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