Author

Roland E. Dolle

Washington University in St. LouisORCID 0000-0001-5574-6019Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Anastasiia OnyshchenkoiD· 1 shared Andrew S.J. YooiD· 1 shared Ariella L. G. Coler-ReillyiD· 1 shared Brittany M. BowmaniD· 1 shared Chorlada PaiboonrungruangiD· 1 shared Damon T. BurrowiD· 1 shared David H. PerlmutteriD· 1 shared Emily WilkersoniD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperGenomics

Anastasiia OnyshchenkoORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 2, 2025

Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons

Eva Klinman, Ji‐Sun Kwon, Roland E. Dolle…·Andrew S.J. Yoo

This study investigates age-related changes in mitochondrial dynamics and autophagy in reprogrammed human neurons, finding that autophagy enhancement can reverse these age-dependent alterations.

1 citation

humanstatistical model

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Cancer BiologybioRxivPreprintFeb 13, 2025

Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism

Julius Chembo, Brittany M. Bowman, Kyle M. LaPak…·Michael B. Major

This paper identifies Pyrimethamine and its derivative WCDD115 as potent inhibitors of NRF2 by targeting DHFR and one-carbon metabolism, with WCDD115 showing 22-fold greater efficacy.

4 citations

humanmetabolomics

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GenomicsbioRxivPreprintApr 10, 2020

Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens

Sandeep Kumar, Jinmei Li, Jiwoong Park…·Timothy R. Peterson

This study identifies that multiple cationic amphipathic drugs (CADs) share molecular similarities with chloroquine and inhibit sphingolipid biosynthesis, suggesting their potential as antiviral agents against diverse pathogens including SARS-CoV-2.

3 citations

humanstatistical model

𝕏 PostBluesky