Emily Wilkerson

Pioneer and Altimeter: Fast Analysis of DIA Proteomics Data Optimized for Narrow Isolation Windows

Pioneer and Altimeter provide fast, accurate analysis of DIA proteomics data, improving peptide coverage and speed compared to existing tools.

Optogenetic Proximity Labeling Maps Spatially Resolved Mitochondrial Surface Proteomes and a Locally Regulated Ribosome Pool

The paper introduces optogenetic proximity labeling to map mitochondrial surface proteomes and ribosome pools, revealing Miro1's role in spatially organizing mitochondrial protein biogenesis.

Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue

This paper introduces VVD-065, a covalent NRF2 inhibitor that enhances NRF2 degradation and sensitizes tumors to therapy, supporting a Phase I clinical trial.

Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism

This paper identifies Pyrimethamine and its derivative WCDD115 as potent inhibitors of NRF2 by targeting DHFR and one-carbon metabolism, with WCDD115 showing 22-fold greater efficacy.

Insulin-Independent Regulation of Type 1 Diabetes via Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator Nidogen-2.

This paper identifies a brown adipose tissue-secreted protein fraction that improves glycemia in T1D mice independently of insulin, with nidogen-2 as a key component that inhibits glucagon secretion.