Marie S. Prevost

This study presents the cryo-EM structure of inactive ADGRV1 and shows it has weak constitutive activation and an alternative activation mechanism distinct from other aGPCRs.

The paper solves cryo-EM structures of human α7 nicotinic receptor nanobody complexes, revealing E3's mechanism of inducing active or desensitized conformations through a N-linked sugar moiety.

This paper describes the generation of nanobodies that act as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor, with distinct functional properties.