Pierre J. Lafaye

The paper introduces an optonanobody that reversibly photoactivates native alpha7 nicotinic receptors without genetic modification, demonstrating its effectiveness in Xenopus oocytes and hippocampal slices.

This study presents the cryo-EM structure of inactive ADGRV1 and shows it has weak constitutive activation and an alternative activation mechanism distinct from other aGPCRs.

This study examines the structural changes in segmented filamentous bacteria during their transition from unicellular to filamentous forms, identifying a novel surface layer and its role in host attachment.

This paper develops a single domain antibody targeting ACE2 that protects against SARS-CoV-2 infection in mice when delivered intranasally.

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.

The paper presents a vCLEM protocol to map Aβ and pTau in AD mouse hippocampus connectomics data, revealing new molecular and structural alterations.

The paper solves cryo-EM structures of human α7 nicotinic receptor nanobody complexes, revealing E3's mechanism of inducing active or desensitized conformations through a N-linked sugar moiety.

This paper describes the generation of nanobodies that act as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor, with distinct functional properties.

The paper uses whole-brain imaging to show that tau pathology in mice propagates retrogradely through brain networks.