Daniel G. Anderson

This study shows that silencing Spp1 in TREM2+ cardiac macrophages reduces atrial fibrosis and suppresses AFib in mice, suggesting a new immunotherapy approach.

CHARIOT-AAV conjugates diverse vectors to AAVs to enable tissue-specific delivery and expanded cargo capacity for large genes.

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.