Oliver L. Eichmüller

Cerebral Organoids Uncover Mechanisms of Neural Activity Changes in Epileptogenesis

This paper uses cerebral organoids to model Tuberous Sclerosis Complex and identifies mechanisms of neural activity changes in epileptogenesis, showing potential for drug testing.

Cellular stress in brain organoids is limited to a distinct and bioinformatically removable subpopulation.

The paper identifies a stress signature in brain organoid scRNA-seq data and introduces Gruffi to remove stressed cells, improving developmental accuracy.

Cerebral organoid model reveals excessive proliferation of human caudal late interneuron progenitors in Tuberous Sclerosis Complex

This study uses cerebral organoids to show that TSC2 mutations cause over-proliferation of caudal late interneuron progenitors, leading to Tuberous Sclerosis Complex.