This study investigates the role of cyclic-AMP/phosphodiesterase signaling in modulating nasal tuft cell calcium responses and IL-25 release using mouse and human models.

bioRxiv · Oct 25, 2026 · PreprintPhysiology

MS4A8B regulates Orai1-dependent Ca2+ influx to control motile cilia function in human nasal epithelial cells

Alexander A. Simon, Ray Z. Ma, Jerry S Rao, Katherine Rozsypalek, Zhongming Ma, Nithin D. Adappa, James N. Palmer, Yobouet Inès Kouakou, Robert J. Lee

This study identifies MS4A8B as a regulator of Orai1-dependent Ca2+ influx in human nasal epithelial cilia, linking it to ciliary function and mucociliary clearance.

bioRxiv · Aug 20, 2026 · PreprintPhysiology

Pseudomonas aeruginosa metabolite 3-oxo-C12HSL induces apoptosis through T2R14 and the mitochondrial calcium uniporter

Zoey A. Miller, Arielle Mueller, Joel C. Thompson, Jordan S. Williams, April Park, Nabil F. Darwich, Yobouet Inès Kouakou, Sarah M. Sywanycz, B. Buchler, Nithin D. Adappa, James N. Palmer, Noam A. Cohen, Ryan M. Carey, Robert J. Lee

This study shows that 3-oxo-C12HSL from Pseudomonas aeruginosa induces apoptosis in HNSCC cells via T2R14 and mitochondrial calcium uniporter.

Cell Calcium · May 5, 2026Peer-reviewedPhysiology

Effects of Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on intracellular calcium, mitochondrial function, and viability in human nasal epithelial cells

Joel C. Thompson, April Park, Yobouet Inès Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee

This study investigates the effects of pyocyanin and 1-hydroxyphenazine on calcium signaling, mitochondrial function, and cell viability in nasal epithelial cells and cancer cell lines.

International Forum of Allergy & Rhinology · Dec 19, 2025Peer-reviewedPhysiology

Human olfactory organoids as an in vitro model of the olfactory epithelium

Kang‐Hoon Kim, Ankit Chauhan, Michael A. Kohanski, Nithin D. Adappa, James N. Palmer, Danielle R. Reed, Noam A. Cohen, Peihua Jiang, Hong Wang, Jennifer E. Douglas

This study generates human olfactory organoids that exhibit immunostaining, gene expression, and odorant-induced Ca2+ mobilization, mimicking olfactory epithelium function.

bioRxiv · Oct 21, 2025 · PreprintCell Biology

Species-level bacterial community profiling of the healthy sinonasal microbiome using Pacific Biosciences sequencing of full-length 16S rRNA genes

Joshua P. Earl, Nithin D. Adappa, Jarosław E. Król, Archana S. Bhat, Sergey V. Balashov, Rachel L. Ehrlich, James N. Palmer, Alan D. Workman, Mariel T. Blasetti, Bhaswati Sen, Jocelyn A. Hammond, Noam A. Cohen, Garth D. Ehrlich, Joshua Chang Mell

The paper presents a pipeline using PacBio CCS to sequence full-length 16S rRNA genes for species-level microbiome analysis, showing high accuracy in mock communities and variation in sinonasal microbiomes.

Microbiome · Oct 23, 2018Peer-reviewedBioinformatics

Tissue dependent expression of bitter receptor TAS2R38 mRNA

Jennifer E. Douglas, Cailu Lin, Corrine J. Mansfield, Charles J. Arayata, Beverly J. Cowart, Andrew I Spielman, Nithin D. Adappa, James N. Palmer, Noam A. Cohen, Danielle R. Reed

The paper investigates whether TAS2R38 mRNA expression in taste tissue correlates with expression in sinonasal tissue among heterozygotes, finding no significant relationship.

Chemical Senses · Oct 19, 2018Peer-reviewedMolecular Biology

Cytokine profile in human olfactory cleft mucus and associated changes in olfactory function

Hong Wang, Cristina Jaén, Keiichi Yoshikawa, Mai Haneoka, Naoko Saito, Junji Nakamura, Nithin D. Adappa, Noam A. Cohen, Pamela Dalton

The paper investigates age-related olfactory loss by analyzing cytokine levels in human olfactory mucus and their association with olfactory function decline.

bioRxiv · May 28, 2018 · PreprintNeuroscience