Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure
Sijie Yang, Yuanling Yu, Yanli Xu…·Yunlong Cao
The paper shows JN.1 outcompetes BA.2.86 and other variants by evading antibodies more effectively, despite reduced ACE2 binding.
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Peking UniversityORCID 0000-0001-5918-1078Unclaimed ORCID profile · follow to get notified of new preprints
36 papers
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Sijie Yang, Yuanling Yu, Yanli Xu…·Yunlong Cao
The paper shows JN.1 outcompetes BA.2.86 and other variants by evading antibodies more effectively, despite reduced ACE2 binding.
Yunlong Cao, Yali Bai, Tianjiao Yuan…·Xiaoliang Sunney Xie
The paper introduces Cabernet, a bisulfite-free single-cell method for high-resolution 5mC and 5hmC profiling, revealing epigenetic dynamics in mouse embryos and demonstrating scalability for complex tissues.
Ayijiang Yisimayi, Weiliang Song, Jing Wang…·Yunlong Cao
This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.
Sijie Yang, Yuanling Yu, Fanchong Jian…·Yunlong Cao
This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.
Chen Chen, Jizhou Li, Lin Di…·Jianbin Wang
MINERVA enables rapid, high-quality SARS-CoV-2 whole genome sequencing from clinical samples by simplifying library preparation and improving viral enrichment.
Shuo Du, Yunlong Cao, Qinyu Zhu…·Junyu Xiao
The paper reports the cryo-EM structure of a potent SARS-CoV-2 NAb, BD-368-2, showing it blocks ACE2 binding and induces structural changes in the spike trimer, distinct from other NAbs.