Brian S. Yandell

Distinct genetic architectures of mRNA expression and splicing QTL in the Diversity Outbred mouse population

The paper maps eQTL, isoQTL, irQTL, and sQTL in DO mice, showing distinct genetic effects on mRNA expression and splicing, and identifies candidate genes and regulatory mechanisms.

Identification of genetic drivers of plasma lipoproteins in the Diversity Outbred mouse population

The paper identifies genetic drivers of plasma lipoproteins in mice and links them to human lipid traits using QTL analysis and GWAS integration.

Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin

The paper identifies Abhd2 as an enzyme involved in metabolizing phosphatidylcholine and cardiolipin using genetic and lipidomic data from Diversity Outbred mice.

Reconstruction of networks with direct and indirect genetic effects

The paper introduces PCgen, an algorithm that reconstructs genetic networks by incorporating direct and indirect effects, improving accuracy using individual data over genotypic means.

Genetic determinants of gut microbiota composition and bile acid profiles in mice

This study identifies genetic loci associated with gut microbiota composition and bile acid profiles in mice using QTL analysis and validation experiments.

Testing pleiotropy vs. separate QTL in multiparental populations

The paper develops statistical methods to test for pleiotropy or separate QTL in multiparental populations and applies them to find two distinct loci in a genomic region of mice.

R/qtl2: software for mapping quantitative trait loci with high dimensional data and multi-parent populations

R/qtl2 is a software tool for QTL mapping in multi-parent populations and high-dimensional data, offering features like linear mixed models and SNP imputation.

Dissecting the genetic architecture of shoot growth in carrot (Daucus carota L.) using a diallel mating design

This paper uses a diallel mating design and Bayesian analysis to study the genetic basis of shoot growth in carrot, finding that non-additive effects significantly influence early growth traits.

Identification of Slco1a6 as a candidate gene that broadly affects gene expression in mouse pancreatic islets

The paper identifies Slco1a6 as a gene affecting gene expression in mouse pancreatic islets through eQTL analysis and functional studies.