Christopher H. Emfinger

Distinct genetic architectures of mRNA expression and splicing QTL in the Diversity Outbred mouse population

The paper maps eQTL, isoQTL, irQTL, and sQTL in DO mice, showing distinct genetic effects on mRNA expression and splicing, and identifies candidate genes and regulatory mechanisms.

A graph-based learning approach to predict the effects of gene perturbations on molecular phenotypes

This paper introduces a graph-based machine learning approach to predict gene perturbation effects on molecular phenotypes using existing experimental data and biological networks.

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells

This paper identifies VDAC1 as the target of SW016789, a hypersecretion inducer, and shows it causes distinct transcriptomic changes in beta-cells compared to ER stress.

Identification of genetic drivers of plasma lipoproteins in the Diversity Outbred mouse population

The paper identifies genetic drivers of plasma lipoproteins in mice and links them to human lipid traits using QTL analysis and GWAS integration.