Alexa Burger

This study shows that rbm8a deficiency in zebrafish causes hematopoietic defects by impairing non-canonical Wnt/PCP signaling, leading to reduced thrombocytes and LPM anomalies.

This study identifies the pericardium's origin from anterior mesothelial progenitors in zebrafish, distinct from the heart field, and links pericardial stiffness to pediatric cardiomyopathies.

The paper establishes phiC31 integrase-based transgene landing sites in zebrafish, enabling efficient and reproducible transgenesis with 25-50% germline transmission efficiency.

The paper identifies conserved notochord-specific enhancers of Brachyury/T/TBXT in vertebrates and shows their role in notochord expression and development.

The paper introduces next-generation transgenesis tools for zebrafish and other species, including vectors with fluorescent markers and promoters for specific tissue expression.

This study identifies Hand2 as a key regulator of mesothelium progenitors in zebrafish and shows its reactivation in mesothelioma, linking developmental processes to disease.

The paper compares zebrafish Switch reporter transgenes to identify those with optimal recombination efficiency and expression patterns for lineage labeling.

The paper identifies a conserved regulatory program driving lateral plate mesoderm emergence across chordates using zebrafish and comparative analysis.

This paper demonstrates efficient CRISPR-Cas9-based gene disruption in the medfly using RNPs, achieving high germline transmission and mutant phenotypes.

This study identifies the yellow ortholog as the brown body locus in houseflies using CRISPR-Cas9 and confirms its role in melanization.

The paper generates two new zebrafish tbx5a frameshift alleles and compares their phenotypes to the classic hst mutant, finding differences in heart defects.

CrispRVariants provides a toolkit to accurately assess mutagenesis efficiency in genome editing experiments by analyzing sequencing data and resolving mutant alleles.