Author

Sidharth Tyagi

Yale UniversityORCID 0000-0001-6097-0541Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

Mohammad‐Reza GhovanlooiD· 2 shared Peng ZhaoiD· 2 shared Stephen G. WaxmaniD· 2 shared Akiko IwasakiiD· 1 shared Chen LiuiD· 1 shared Dmytro V. VasylyeviD· 1 shared Edward Yang· 1 shared Étienne CaroniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Mohammad‐Reza GhovanlooORCID

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3 papers

Recent·Most cited

NeuroscienceThe Journal of General PhysiologyPeer-reviewedOct 30, 2026

Combinatorial logic of Nav channels in nociceptor excitability: Different degrees of synergy define distinct neuronal groups

Dmytro V. Vasylyev, Sidharth Tyagi, Mohammad‐Reza Ghovanloo…·Stephen G. Waxman

The paper investigates how combinations of Nav1.7 and Nav1.8 channels affect nociceptor excitability, showing that their synergistic effects vary across neuronal subtypes.

1 citation

electronic health recordsexperimental assay

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ImmunologyNature Machine IntelligencePeer-reviewedDec 31, 2025

ImmunoStruct: a multimodal neural network framework for immunogenicity prediction from peptide-MHC sequence, structure, and biochemical properties

Kevin Bijan Givechian, João Felipe Rocha, Chen Liu…·Smita Krishnaswamy

ImmunoStruct improves immunogenicity prediction by integrating peptide-MHC sequence, structure, and biochemical data, showing better performance than existing methods.

7 citations

protein sequenceprotein structure

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NeurosciencebioRxivPreprintFeb 4, 2025

Targeted ubiquitination of NaV1.8 reduces sensory neuronal excitability

Sidharth Tyagi, Mohammad‐Reza Ghovanloo, Matthew Alsaloum…·Sulayman D. Dib‐Hajj

This study develops a therapeutic protein, UbiquiNaV, that reduces NaV1.8 channel expression in sensory neurons, alleviating pain in preclinical models.

7 citations

mouseexperimental assay

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