Benoît P. Nicolet

PAIR-Scan: Single-step identification of highly potent TCR-neoantigen pairs through library-on-library screening

PAIR-Scan identifies potent TCR-neoantigen pairs from tumor samples through library-on-library screening, enabling efficient analysis of T cell reactivity.

Decoding translational control by cis-regulatory elements and RNA binding proteins in human effector T cells

The paper identifies RNA binding proteins and cis-regulatory elements that control translation in human effector T cells through multi-omics and machine learning analysis.

The carbon footprint of science when it fails to self-correct

The paper estimates the carbon footprint of continued research on an irreproducible genetic association, finding it to be approximately 30,068 tons of CO2 equivalent.

Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data

The paper benchmarks eight tools for identifying and quantifying alternative polyadenylation sites from RNA-seq data using real, synthetic, and 3'-end sequencing data.

Circular RNAs exhibit limited evidence for translation, or translation regulation of the mRNA-counterpart in terminal hematopoiesis

The paper analyzes circRNA expression during hematopoietic differentiation and finds limited evidence for their translation or regulatory role in erythroid and megakaryoid cells.