Daniel H. Goldhill

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

The paper introduces Flu Mutation Explorer, a web tool that integrates IAV genomic data with mutation annotations to help interpret host adaptation mutations.

This study tracks the emergence and molecular evolution of H5N1 influenza viruses in U.S. dairy cattle, identifying increased mutation rates and positive selection after spillover from birds.

Cattle B3.13 H5N1 polymerase gained PB2 M631L and PA K497R, boosting replication in bovine and human cells via better bovine ANP32A use; later PB2 E627K and D740N add activity.

This study identifies novel mammalian adaptive mutations in avian influenza polymerase complex using phylogenetic analysis and experimental assays.

The study shows cow mammary gland cells can support replication of multiple IAV strains and are susceptible to co-infection with human and avian IAVs, suggesting the udder may act as a site for viral reassortment.