Author

Alexander W. Cook

University of SheffieldORCID 0000-0001-6309-8998Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Christopher P. ToselandiD· 2 shared Isabel W. Shahid-Fuente· 2 shared Jesse AaroniD· 2 shared Lin WangiD· 2 shared Natalia FiliiD· 2 shared Teng‐Leong ChewiD· 2 shared Abdulmohsen AlanaziiD· 1 shared Alexandra Moreno Mitchell· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Christopher P. ToselandORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 2, 2026

Nuclear Myosin VI stabilises Ku-associated DNA ends during non-homologous end joining

Abdulmohsen Alanazi, Alexander W. Cook, Isabel W. Shahid-Fuente…·Christopher P. Toseland

This study identifies myosin VI as a regulator of DNA double-strand break repair, linking ATM signalling to Ku-associated DNA-end stabilisation and suggesting potential therapeutic targeting.

DOI 10.64898/2026.09.01.748478

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivPreprintNov 13, 2025

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells.

Yukti Hari‐Gupta, Danielle Lambert, Isabel W. Shahid-Fuente…·Christopher P. Toseland

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

2 citations

humanbulk RNA-seq

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