Teng‐Leong Chew

This study identifies myosin VI as a regulator of DNA double-strand break repair, linking ATM signalling to Ku-associated DNA-end stabilisation and suggesting potential therapeutic targeting.

The paper introduces a machine learning-enabled pipeline for volumetric FLIM imaging in living systems, enabling long-term and high-speed data acquisition and analysis.

This paper presents a device for adapting upright light sheet fluorescence microscopy to image samples at air-liquid interface, demonstrating its use on three biological specimens.

OpticalFlow3D measures amorphous motion in 3D fluorescence microscopy images without requiring segmentation or prior motion definitions.

This study shows that septins form mechanosensitive networks under the nucleus to protect it from mechanical stress.

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

The paper shows that neutrophils use endothelial membrane tunnels for paracellular extravasation, formed by membrane lifting and indentation without requiring PECAM-1 or VE-cadherin.

The paper uses super-resolution microscopy to visualize a chromatin loop in human cells and validates the results with Hi-C data.