David Fernández de Sevilla

GENERATION OF FUNCTIONAL NEURONS FROM ADULT HUMAN MUCOSAL OLFACTORY ENSHEATHING GLIA BY DIRECT LINEAGE CONVERSION

This paper demonstrates that adult human mucosal olfactory ensheathing glia can be directly reprogrammed into neurons using NEUROD1, showing neuronal features and functionality in vivo.

Bidirectional Modulation Of Synaptic Transmission By Insulin-Like Growth Factor I

This paper shows that IGF-I modulates synaptic plasticity in a concentration-dependent manner, inducing LTP or LTD at cortical synapses.

IGF-1 facilitates extinction of conditioned fear

This study shows IGF-1 enhances fear extinction memory by modulating synaptic plasticity and neuronal excitability in the infralimbic cortex.

IGF-I Governs Cortical Inhibitory Synaptic Plasticity By Astrocyte Activation

This study shows that IGF-I signaling in astrocytes regulates inhibitory synaptic plasticity and behavior by inducing LTD through ATP/adenosine release and A2A receptor activation.