Ignacio Torres‐Alemán

A small molecule IGF-1 sensitizer reversed cognitive decline and reduced amyloid-beta levels in a mouse model of Alzheimer's disease.

This study shows that AIK3, an IGF-1 sensitizer, improves sensorimotor, neurological, and cognitive functions in mice with mild TBI.

This study shows that circulating IGF-1 signals physical vigor to the brain via orexin and VTA neurons, modulating physical activity and exercise reward.

The paper investigates how lifestyle factors like isolation and high-fat diet affect brain sensitivity to IGF-1 in mice, showing reduced neuronal responses to systemic IGF-1 and linking this to mood disturbances.

This study examines the effects of mild intensity physical exercise on EEG frequency bands in healthy young adults, finding increased Alpha activity and trends in Theta activity.

This paper shows that IGF-I modulates synaptic plasticity in a concentration-dependent manner, inducing LTP or LTD at cortical synapses.

This study investigates the role of astrocytic IGF-IR in ischemic injury, finding that its deletion leads to larger lesions and worse outcomes.

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.

This study shows that IGF-I regulates circadian feeding behavior and metabolism via hypothalamic orexin neurons in mice.

This study shows that IGF-I modulates sleep by regulating orexin neurons in the hypothalamus, affecting sleep architecture and electrocorticographic patterns in mice.

This study shows that IGF-I signaling in astrocytes regulates inhibitory synaptic plasticity and behavior by inducing LTD through ATP/adenosine release and A2A receptor activation.

This study shows that IGF-I modulates stress vulnerability via orexin neurons, with Firoc mice lacking IGF-I receptors in these neurons showing heightened fear responses and PTSD-like behaviors.

This study shows that insulin receptors in astrocytes are necessary for brain uptake of circulating insulin and glucose.