Jaime Pignatelli

This study shows that AIK3, an IGF-1 sensitizer, improves sensorimotor, neurological, and cognitive functions in mice with mild TBI.

The paper investigates how lifestyle factors like isolation and high-fat diet affect brain sensitivity to IGF-1 in mice, showing reduced neuronal responses to systemic IGF-1 and linking this to mood disturbances.

This study investigates the role of astrocytic IGF-IR in ischemic injury, finding that its deletion leads to larger lesions and worse outcomes.

This study shows that exercise in mice can transmit cognitive benefits to the second generation through miRNA-mediated mechanisms, even when cellular changes in the first generation are lost.

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.

This study shows that IGF-I regulates circadian feeding behavior and metabolism via hypothalamic orexin neurons in mice.

This study shows that IGF-I modulates sleep by regulating orexin neurons in the hypothalamus, affecting sleep architecture and electrocorticographic patterns in mice.

This study shows that IGF-I signaling in astrocytes regulates inhibitory synaptic plasticity and behavior by inducing LTD through ATP/adenosine release and A2A receptor activation.

This study shows that IGF-I modulates stress vulnerability via orexin neurons, with Firoc mice lacking IGF-I receptors in these neurons showing heightened fear responses and PTSD-like behaviors.