Jonathan Adrian Zegarra-Valdivia

This study shows that astrocytic insulin receptors modulate food valence by affecting orexin neuron responses to food in mice.

A small molecule IGF-1 sensitizer reversed cognitive decline and reduced amyloid-beta levels in a mouse model of Alzheimer's disease.

This study shows that AIK3, an IGF-1 sensitizer, improves sensorimotor, neurological, and cognitive functions in mice with mild TBI.

This study shows that circulating IGF-1 signals physical vigor to the brain via orexin and VTA neurons, modulating physical activity and exercise reward.

The paper investigates how lifestyle factors like isolation and high-fat diet affect brain sensitivity to IGF-1 in mice, showing reduced neuronal responses to systemic IGF-1 and linking this to mood disturbances.

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.

This study shows that IGF-I modulates sleep by regulating orexin neurons in the hypothalamus, affecting sleep architecture and electrocorticographic patterns in mice.

This study shows that IGF-I signaling in astrocytes regulates inhibitory synaptic plasticity and behavior by inducing LTD through ATP/adenosine release and A2A receptor activation.

This study shows that IGF-I modulates stress vulnerability via orexin neurons, with Firoc mice lacking IGF-I receptors in these neurons showing heightened fear responses and PTSD-like behaviors.