Jansen Fernandes

This study shows that circulating IGF-1 signals physical vigor to the brain via orexin and VTA neurons, modulating physical activity and exercise reward.

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.

This study shows that IGF-I signaling in astrocytes regulates inhibitory synaptic plasticity and behavior by inducing LTD through ATP/adenosine release and A2A receptor activation.