Ana Maria Fernandez

This study investigates the role of astrocytic IGF-IR in ischemic injury, finding that its deletion leads to larger lesions and worse outcomes.

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.

This study shows that IGF-I modulates sleep by regulating orexin neurons in the hypothalamus, affecting sleep architecture and electrocorticographic patterns in mice.

This study shows that IGF-I signaling in astrocytes regulates inhibitory synaptic plasticity and behavior by inducing LTD through ATP/adenosine release and A2A receptor activation.

This study shows that insulin receptors in astrocytes are necessary for brain uptake of circulating insulin and glucose.