Author

Yijun Xiong

Scripps Research InstituteORCID 0000-0001-6348-9649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Benjamin F. CravattiD· 2 shared Adrianna M. TurneriD· 1 shared Althea Hansel-HarrisiD· 1 shared Benjamin Silva· 1 shared Bruno N. MelilloiD· 1 shared Christopher J. ReinhardtiD· 1 shared Christopher J. SmedleyiD· 1 shared Daria Van TyneiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Benjamin F. CravattORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

Kyong Tkhe Fam, Pavan Kumar Chodisetti, Zifei Wang, Joshua A. Homer, Christopher J. Smedley, Seiya Kitamura, Benjamin Silva, Yijun Xiong, Althea Hansel-Harris, Matthew Holcomb, Simeon Babarinde, Adrianna M. Turner, Daria Van Tyne, Ian A. Wilson, Stefano Forli, , Howard C. Hang

This study shows that inhibiting SagA, a peptidoglycan hydrolase, increases vancomycin susceptibility in VREfm through both genetic and pharmacological approaches.

Nature Communications · Jun 15, 2026Peer-reviewedMicrobiology

A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAP

Yijun Xiong, Christopher J. Reinhardt, Tracey Nguyen, Melissa A. Hoffman, Gabriel M. Simon, Bruno N. Melillo, Benjamin F. Cravatt

The paper compares acrylamide and butynamide stereoprobes to identify covalent inhibitors of the actin maturation protease ACTMAP in human cancer cells.

Journal of the American Chemical Society · May 20, 2026Peer-reviewedBiochemistry