Julio Esparza

This study shows that circulating IGF-1 signals physical vigor to the brain via orexin and VTA neurons, modulating physical activity and exercise reward.

The paper introduces the Structure Index (SI), a graph-based metric to quantify feature distribution in arbitrary dimensional spaces, demonstrating its application to neuroscience and data science.

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.