Kentaro Suda

This study shows that circulating IGF-1 signals physical vigor to the brain via orexin and VTA neurons, modulating physical activity and exercise reward.

This study investigates the role of astrocytic IGF-IR in ischemic injury, finding that its deletion leads to larger lesions and worse outcomes.

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.