Charles K. F. Chan

This study identifies Basigin's role in GC-induced bone loss and impaired angiogenesis by linking altered skeletal stem cell dynamics to vascular dysfunction, showing that anti-Basigin therapy can reverse these effects.

This paper identifies CCN3 as a brain-derived hormone that promotes bone mass in lactating females by compensating for estrogen loss and supporting skeletal stem cells.

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

On patterned flow cells using exclusion amplification, up to 5-10% of reads are credited to the wrong sample in a pool, traced to free index primers surviving library cleanup.