Timothy A. Springer

This paper presents AB-FEP, a computational method to classify integrin-binding ligands by their conformational preference, showing high accuracy and insights into ligand mechanisms.

The paper develops a synthetic Fab yeast display library integrated with machine learning to discover antibodies against cell surface antigens, yielding hundreds of validated antibodies and a public dataset.

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

This study shows that the I-domain of TRAP in Plasmodium parasites mediates adhesion and that its cationic charge and polyspecificity are critical for infectivity.