Author

Richard Siller

University of Massachusetts Chan Medical SchoolORCID 0000-0001-6691-9261Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Aleksandra A. GalitsynaiD· 1 shared Anbin CheniD· 1 shared Bjørn Christian Lundberg· 1 shared Charalampos TzoulisiD· 1 shared Denis L. Lafontaine· 1 shared Emily NavarreteiD· 1 shared Evandro Fei FangiD· 1 shared Gareth J. SullivaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Aleksandra A. GalitsynaORCID

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2 papers

Recent·Most cited

Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation

Xiangru Huo, Denis L. Lafontaine, Thomas M. Reimonn, Liyan Yang, Richard Siller, Jack D. Huey, Jiang Min, Aleksandra A. Galitsyna, Vedat Yilma, Krishna Mohan Parsi, Emily Navarrete, Hoang Tran, Leonid A. Mirny, René Maehr, Johan Harmen Gibcus, , Nezar A. Abdennur

The paper temporally maps nuclear reorganization during human stem cell differentiation and identifies three temporally ordered transitions in nuclear structure and function.

bioRxiv · Sep 18, 2026 · PreprintGenomics

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease

Yu Hong, Zhuoyuan Zhang, Tsering Yangzom, Anbin Chen, Bjørn Christian Lundberg, Evandro Fei Fang, Richard Siller, Gareth J. Sullivan, J Zeman, Charalampos Tzoulis, Laurence Albert Bindoff, Kristina Xiao Liang

This study uses iPSC-derived cortical organoids to model Alpers' disease and shows that nicotinamide riboside improves mitochondrial defects and neuronal loss.

International Journal of Biological Sciences · Jan 1, 2024Peer-reviewedNeuroscience