Author

Lenno Krenning

The Netherlands Cancer InstituteORCID 0000-0001-6696-0512Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

René H. MedemaiD· 2 shared Ben MorrisiD· 1 shared Boudewijn M.T. BurgeringiD· 1 shared Cor LieftinkiD· 1 shared Daimy van der Ven· 1 shared Femke M. FeringaiD· 1 shared Hester Heimans· 1 shared Jeroen van den BergiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenomics

René H. MedemaORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintJul 13, 2021

Performance of large scale pooled CRISPR screens is dependent on Cas9 expression levels

João M. Fernandes Neto, Cor Lieftink, Katarzyna Jastrzebski…·Roderick L. Beijersbergen

This study shows that Cas9 expression levels significantly affect the efficiency and speed of large-scale pooled CRISPR screens, with higher Cas9 expression improving performance.

2 citations

humanCRISPR screen

𝕏 PostBluesky

Molecular BiologyCell ReportsPeer-reviewedJan 1, 2021

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

Marten Hornsveld, Femke M. Feringa, Lenno Krenning…·Boudewijn M.T. Burgering

The paper identifies a FOXO-dependent mechanism that restricts proliferation of cells with mild replication stress by promoting premature activation of APC/CCDH1.

27 citations

experimental assay

𝕏 PostBluesky