Michael Anthony Hollingsworth

This paper establishes patient-derived models of neuroendocrine prostate cancer (NEPC) from metastases, showing they retain tumor heterogeneity and can model metastatic progression.

This study identifies Dec2 as a circadian gene that promotes pancreatic cancer dormancy by reducing MHC-I antigen presentation, enabling immune evasion.

This study uses AI-driven proteomics to identify molecular transitions in pancreatic cancer precursors, revealing early molecular changes in histologically normal tissue.

This study identifies an iron-regulated signaling pathway involving MSRA and PKA that drives adipose browning and cancer cachexia, showing that MsrA deletion reduces cachexia in PDA models.

This study analyzes the spatial collagen proteome in normal breast tissue, linking it to BI-RADS categories and BMI through proteomic and imaging analyses.

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

This study uses an Oncopig model to show that selective KRASG12D mutation in pancreatic epithelial cells drives neoplasia and stromal changes similar to human PDAC.

This study links radiomic features to genome-wide associations in pancreatic cancer to identify driver genes associated with tumor structural heterogeneity and patient survival.