David van Bruggen

The paper profiles histone modifications in adult human CNS cells, revealing epigenetic memory of developmental programs in oligodendroglia.

The paper identifies regional glial heterogeneity in human white matter using single nucleus RNA sequencing, revealing tissue-specific glial populations and age/sex-related gene expression differences.

This study identifies an early wave of oligodendrogenesis in the human forebrain at PCW 8 using single-cell RNA-Seq and ATAC-Seq, supported by spatial gene expression analysis.

The paper identifies distinct oligodendrocyte populations with spatial preferences and differential responses to spinal cord injury.

Unspliced versus spliced mRNA in standard scRNA-seq gives RNA velocity, a per-cell vector predicting future state over hours, validated in neural crest and used to trace mouse hippocampal lineages.

The paper uses single-cell transcriptomics to show that embryonic Pdgfra+ cells give rise to OPCs with convergent transcriptional profiles in different CNS regions.