Author

Luise A. Seeker

Stanford UniversityORCID 0000-0001-6375-6372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Organism:human· 5 Research Focus:gene regulatory network inference· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Anna WilliamsiD· 3 shared Nadine Bestard-Cuche· 3 shared David van BruggeniD· 2 shared Fabio Baldivia PohliD· 2 shared Gonçalo Castelo‐BrancoiD· 2 shared Mukund KabbeiD· 2 shared Neil Cowan HendersoniD· 2 shared Nina-Lydia KazakouiD· 2 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Anna WilliamsORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Engulfment by brain macrophages in a short-lived vertebrate

Rahul Nagvekar, Angela N. Pogson, Prateek R Kalakuntla, Helena J. Barr, Azalia M. Martínez Jaimes, SV Perry, Emma K. Costa, Jingxun Chen, Felix Boos, Paloma Navarro Negredo, Luise A. Seeker, James Brian Jaggard, Rogelio Barajas, Philippe Mourrain, Param Priya Singh, , Anne Brunet

This study identifies brain macrophages in the African turquoise killifish that engulf brain extracellular material, showing age-related decline in engulfment capacity.

bioRxiv · Apr 29, 2026 · PreprintCell Biology

Tabula Sapiens reveals the non-coding RNA landscape across 22 human organs and tissues

Jaeyoon Lee, Madhav Mantri, Kavita Murthy, Luise A. Seeker, George Crowley, Robert C. Jones, Stephen R. Quake

The paper expands Tabula Sapiens to include non-coding RNA data from 22 human tissues, revealing cell type-specific expression and subcellular localization patterns of non-coding RNAs.

bioRxiv · Mar 25, 2026 · PreprintCell Biology

Mapping the glial transcriptome in Huntington's disease using snRNAseq: Selective disruption of glial signatures across brain regions

Sunniva M. K. Bøstrand, Luise A. Seeker, Nadine Bestard-Cuche, Nina-Lydia Kazakou, Sarah Jäkel, Boyd Kenkhuis, Neil Cowan Henderson, Susanne Tamara de Bot, Willeke van Roon‐Mom, Josef Priller, Anna Williams

This study uses snRNAseq to analyze glial cell heterogeneity in Huntington's disease across brain regions, identifying subtype-specific changes and potential mechanisms of glial dysfunction.

Acta Neuropathologica Communications · Oct 20, 2024Peer-reviewedNeuroscience

Cell type-specific effects of age and sex on human cortical neurons

Jo-fan Chien, Hanqing Liu, Bang-An Wang, Chongyuan Luo, Anna Bartlett, Rosa Castanon, Nicholas D. Johnson, Joseph R. Nery, Julia K. Osteen, Junhao Li, Jordan Altshul, Mia A. Kenworthy, Cynthia Valadon, Michelle Liem, Naomi Claffey, , Eran A. Mukamel

The paper examines age and sex effects on human cortical neurons using multiomic data, finding age-related changes in gene expression and DNA methylation, and sex differences in gene expression and X-inactivation escape.

Neuron · Jun 5, 2024Peer-reviewedNeuroscience

Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programs

Mukund Kabbe, Eneritz Agirre, Karl E. Carlström, Fabio Baldivia Pohl, Nicolas Ruffin, David van Bruggen, Mandy Meijer, Luise A. Seeker, Nadine Bestard-Cuche, Alex R. Lederer, Jilin Zhang, Virpi Ahola, Steven A. Goldman, Marek Bartošovič, Maja Jagodic, , Gonçalo Castelo‐Branco

The paper profiles histone modifications in adult human CNS cells, revealing epigenetic memory of developmental programs in oligodendroglia.

bioRxiv · Apr 15, 2024 · PreprintNeuroscience

Marked regional glial heterogeneity in the human white matter of the central nervous system

Luise A. Seeker, Nadine Bestard-Cuche, Sarah Jäkel, Nina-Lydia Kazakou, Sunniva M. K. Bøstrand, Laura J. Wagstaff, Justyna Cholewa-Waclaw, Alastair Morris Kilpatrick, David van Bruggen, Mukund Kabbe, Fabio Baldivia Pohl, Zahra Moslehi, Neil Cowan Henderson, Catalina A. Vallejos, Gioele La Manno, , Anna Williams

The paper identifies regional glial heterogeneity in human white matter using single nucleus RNA sequencing, revealing tissue-specific glial populations and age/sex-related gene expression differences.

Acta Neuropathologica Communications · May 22, 2023Peer-reviewedNeuroscience