Sarah Jäkel

Brain Region-Specific Oligodendrocyte States Highlight Mitochondrial Gene Upregulation and Loss of Canonical Identity Signatures in Alzheimers Disease

The paper identifies region- and disease-specific transcriptomic changes in oligodendrocytes from Alzheimer's disease patients using single-nucleus RNA sequencing.

Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glia responses

The paper uses single nuclei RNAseq to identify distinct glial gene expression patterns in MS patients, revealing subgroup-specific pathological processes and suggesting precision medicine approaches.

Mapping the glial transcriptome in Huntington's disease using snRNAseq: Selective disruption of glial signatures across brain regions

This study uses snRNAseq to analyze glial cell heterogeneity in Huntington's disease across brain regions, identifying subtype-specific changes and potential mechanisms of glial dysfunction.

Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer's disease

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

Marked regional glial heterogeneity in the human white matter of the central nervous system

The paper identifies regional glial heterogeneity in human white matter using single nucleus RNA sequencing, revealing tissue-specific glial populations and age/sex-related gene expression differences.